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Structural Modification 3: C18 Fatty Diacid Lipidation The Mechanism of Half-Life Extension The most consequential structural modification in cagrilintide -- and the one that defines it as a "long-acting" analog -- is the attachment of a C18 fatty diacid chain via a structured hydrophilic linker

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Some participants achieved weight loss of approximately 24% of body weight at 48 weeks approaching levels reported with some bariatric surgical procedures, though no direct head-to-head comparisons have been conducted and long-term durability beyond the trial period remains unknown

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